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Can CBD Oil Help Lupus? | What Science Says

The topic of CBD oil is one that’s widely discussed and often debated. There is promising research showing that CBD has several potential medicinal benefits for specific conditions. Therefore, CBD oil has become a trend when it comes to treating conditions involving pain and inflammation, and even depression and anxiety. But can CBD oil help lupus disease?

A lupus diagnosis can be devastating. The condition causes the body’s immune system to attack its own tissues, and it can affect internal organs, including the heart, brain, and lungs. Every year, doctors diagnose 16,000 new cases of lupus. There are approximately 5 million people living with this life-altering autoimmune disease around the world.

Although lupus affects so many people, it’s a difficult disease to diagnose. It’s also challenging to treat because of its unusually wide and varied array of possible symptoms. Fortunately, CBD oil seems to offer some benefits for lupus patients. In this article, we will take a closer look at how CBD may help with lupus.

What Is Lupus?

Lupus is a long-term autoimmune disease in which the immune system becomes hyperactive and attacks normal, healthy tissue. Symptoms include swelling, inflammation, and damage to the joints, kidneys, heart, lungs, skin, and blood.

Because of its complex nature, people often refer to lupus as the “disease of 1,000 faces.” Lupus isn’t a contagious disease. It cannot be transmitted sexually or in any other way to another person. However, in rare cases, women with lupus could give birth to children who then develop a form of lupus, known as neonatal lupus.

The early symptoms of lupus vary widely but may include joint pain, fever, chest pain, swelling, headaches, skin lesions, and fatigue. The most distinctive symptom is a butterfly-shaped rash that spreads across the cheeks – but not all patients experience this.

Most lupus patients experience symptomatic flare-ups that could worsen without successful treatment to manage the condition. Over time, lupus can cause neurological issues, kidney damage, and a heightened risk of lung, heart, and blood vessel conditions.

Doctors believe that a combination of environmental factors and genetic predisposition triggers lupus. Certain types of medications (antibiotics, blood pressure drugs, and anti-seizure), infections, and even exposure to sunlight can also trigger the disease. The majority of patients receive a diagnosis between ages 15 and 45.

CBD Oil for Lupus

So far, there hasn’t been any research done on CBD oil specifically for lupus. However, a growing body of evidence suggests that it may help treat a few aspects of it.

Due to the lack of research, we need to go on what we know about CBD in general, along with what we understand from research on similar symptoms or pathology. CBD oil as a potential treatment option is likely to get attention from lupus researchers for several reasons, which we will outline below.

CBD and Lupus Symptoms

A wealth of research suggests that CBD is very effective in relieving pain and inflammation. One of the primary symptoms of lupus is considerable amounts of inflammation.

Lupus May Cause an Epidemic of Pain

Lupus contributes to an outburst of pain, including both untreated and undertreated pain. Current treatment options are by no means perfect, and drug companies have a significant financial incentive to find more effective medications.

Opioid Addiction Epidemic

Opioid addiction and overdosing is a major problem in society. Several studies have reported that when marijuana becomes legal in a state, the number of opioid prescriptions – and overdose-related deaths – drops. That’s sure to get the attention of doctors everywhere.

Anecdotal Evidence

There is a lot of anecdotal evidence from people who suffer from lupus, claiming that CBD (or cannabis) is an effective treatment. While this cannot substitute scientific proof, it’s another thing to get doctors and scientists interested.

How Can CBD Oil Help with Lupus

According to the World Health Organization (WHO), studies have proven that CBD has some anti-inflammatory, antioxidant, and immune-system regulating effects. CBD can also change how the brain responds to pain, making it feel less intense and reducing the need for pain medication.

Pain and inflammation are two major side effects of lupus, and CBD oil can help to relieve both, without the adverse side effects that many prescription medications have. CBD helps to increase the levels of anti-inflammatory protein interleukin-10, and also decrease the levels of pro-inflammatory protein interleukin-2.

CBD also appears to suppress particular components of the immune system. Because of how it affects the immune system, CBD oil can help calm the abnormal immune response that is a characteristic of lupus.

CBD also helps treat symptoms of abdominal cramping and nausea – often severe side effects of commonly prescribed drugs for lupus, such as corticosteroids and Plaquenil.

The Link Between Cannabis and Lupus?

Although there is a lack of research concerning lupus and CBD oil, specifically, research studies have investigated cannabis and autoimmune diseases.

According to research published on PubMed.org, preliminary studies suggest that cannabis may be a viable treatment option for autoimmune diseases. Cannabinoids, like CBD, have been shown to act as potent anti-inflammatories and immunosuppressants. Cannabis has shown to mediate beneficial effects in a variety of autoimmune diseases, such as septic shock, rheumatoid arthritis, diabetes, and allergic asthma.

According to Adie Rae, Ph.D., who is a scientific executive at Smart Cannabis, scientific evidence into the role of the endocannabinoid system (ECS) in the treatment of autoimmune diseases is just emerging.

For certain autoimmune diseases, like Crohn’s disease, promising preliminary work already exists. Researchers report that patients with Crohn’s disease who use cannabis are less likely to have severe side effects and end up in hospital when compared to those who don’t use cannabis.

However, clinical evidence is not as far along for other autoimmune diseases.

Final Thoughts on CBD Oil for Lupus

So can CBD oil help lupus? It might. Researchers are looking at CBD and lupus because lupus is an autoimmune disease in which the immune system basically attacks healthy tissue. CBD is known for helping to regulate the immune system, which means that it could have some very beneficial effects. However, scientific evidence is still very limited.

CBD oil may provide benefits to help control the autoimmune response and alleviate the associated symptoms of lupus, such as pain and inflammation. However, keep in mind that you should always talk to your doctor before you start using any other medication, including CBD oil.

CBD has many potential benefits, but could it help patients suffering from lupus? Here's all you need to know about CBD and this autoimmune disease.

Is CBD Oil for Lupus Safe or Effective?

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Richard N. Fogoros, MD, is a retired professor of medicine and board-certified internal medicine physician and cardiologist.

CBD oil, which is derived from marijuana, has become a trend when it comes to treating diseases involving pain and inflammation. But is it effective for lupus?

So far, we don’t have conclusive evidence that CBD oil can safely treat lupus, but research is currently being conducted to help make this possible.  

Because medical marijuana is still fairly controversial, and the laws are confusing, there’s a lot of confusion and misinformation out there about CBD. That can make people hesitant to try it. Good news though—a new law is simplifying the matter for many of us.

What Is CBD Oil?

CBD is short for “cannabidiol.” While it comes from cannabis, it doesn’t get you high because it doesn’t have psychoactive properties. The high comes from a different chemical in the plant called THC (tetrahydrocannabinol).

Marijuana growers focus on strains and techniques that increase THC levels. Cannabis that’s grown for hemp tends to have a lot more CBD than THC.

If you look online, you can find a lot of huge claims about using CBD oil for medicinal purposes. Claims are so glowing, in fact, that you might start to wonder if they can possibly be true. Certainly, when they come from websites that promote marijuana legalization and use, you may be wise to question the veracity.

It’s too early in the research process for us to be able to say “yes” about many of the claims. However, we’re learning enough to be able to say “it’s possible,” or even, “we think so.”

CBD oil is used to treat a host of different conditions, although it’s not approved for any of these conditions, as of mid-2018:  

  • Chronic pain and inflammation
  • Fibromyalgia
  • Glaucoma pain
  • Epilepsy
  • Anxiety
  • Sleep disorders, including insomnia and nightmares
  • Bipolar disorder
  • Multiple sclerosis
  • Parkinson’s disease
  • Schizophrenia
  • Movement disorders (Huntington’s disease)
  • Assistance with smoking cessation
  • Stopping the growth of cancerous tumors

When it comes to taking CBD oil, you have a lot of options: smoking, taking capsules, drops or sprays under the tongue, and as a topical ointment. Research in the United States is in the early stages,   though, since for decades, legal restrictions made it extremely difficult to study the medical benefits of marijuana.

CBD Oil for Lupus

With a lack of research on CBD oil for lupus, we have to go on what we know about CBD in general and can understand from research into conditions with similar symptoms or pathology. This potential treatment is likely to get attention from lupus researchers eventually, though, for several reasons.

  • Lupus contributes to an epidemic of pain, including untreated and undertreated pain. Current treatments are far from perfect, so drug companies have a sizable financial incentive to find more effective medications.
  • The opioid addiction/overdose epidemic is a huge problem for society and puts a lot of strain on the resources of the medical community as well as law enforcement. Meanwhile, several studies have shown that when marijuana becomes legal in a state, the number of opioid prescriptions—and overdose deaths—drops.   That’s bound to get the attention of doctors who want to protect their patients, law enforcement agencies battling the problem, and lawmakers seeking solutions.
  • A wealth of research suggests that CBD oil is effective against pain and inflammation. In its pure form, it’s generally regarded as safe. Lupus involves considerable inflammation.
  • We have abundant anecdotal evidence from people with lupus who say it’s effective. That can’t substitute for scientific proof, but it’s one more thing that gets doctors interested.

Additionally, a 2018 study published in Cellular Immunology found that CBD may alter T-cell activity after spinal cord injury.   Abnormal activity of T-cells (which are part of the immune system) are believed to be involved in lupus.

Lupus can include pain from neuropathy (nerve damage), and multiple studies suggest that CBD can alleviate that type of pain from diabetes, HIV, and other sources.

CBD Side Effects

We probably don’t yet know all of the possible side effects of CBD. Some side effects that have been reported are:

  • Changes to liver enzymes used to process drugs
  • Dry mouth
  • Low blood pressure
  • Lightheadedness
  • Drowsiness
  • Increased tremor in Parkinson’s disease (at high doses)

The World Health Organization says CBD oil may also:  

  • Alter hormonal levels
  • Stimulate the immune system at low levels, and suppress it at higher levels

CBD doesn’t appear to lead to addiction or abuse. It’s also believed to have a low toxicity level, which means it takes a lot to cause an overdose.

Is CBD Legal?

You’d think the question of whether CBD is legal would get a straightforward, yes or no answer, but the legality issue can be confusing.

A lot of pro-marijuana websites have long claimed that it’s legal in all 50 states as long as it doesn’t have more than 0.3 percent THC. They based that argument on the provisions of a specific farm bill. But in 2018, the 9th Circuit Court of Appeals ruled that the old bill didn’t apply to hemp or products derived from it.  

Then came the 2018 Farm Bill. This piece of legislation was wildly popular in both the Senate, where it was passed in June of 2018, and the House, where it was passed in December of 2018 and then quickly signed into law.   It re-classifies hemp as a legal agricultural product, which makes CBD products legal at the federal level.

In states where marijuana and/or CBD is legal, there’s no longer a clash between state and federal law, so the products are legally safe to use. Still, some states have specific laws on the books banning hemp products. So what does the new Farm Bill mean for those states?

Technically, federal law overrules state law. However, that doesn’t mean those states will stop arresting and trying people for CBD use, especially if they want to challenge the new federal law. If you’re in one of those states, talk to an expert about any possible trouble you could get into for using CBD products. The website ProCon.org has information about which states have laws specific to CBD oil. A site called Governing maintains a map of where marijuana is legal in some form.

The only form of CBD that is FDA-approved is Epidiolex, a purified formulation of CBD used for rare forms of epilepsy.   All the other CBD sources being enthusiastically marketed today are unregulated. They often contain amounts of CBD that are substantially different (too much or too little) than the labels indicate, and frequently contain higher levels of THC (the intoxicating chemical found in marijuana) than is permitted in a legitimate CBD product. Anyone electing to use CBD today will need to be cautious and ideally should consult with their physician before doing so.

A Word From Verywell

Treatment decisions should never be taken lightly, and that applies to “natural” treatments like CBD as well—especially when you take the law into account. Consider the pros and con carefully, and be sure to discuss this option with your doctor. Even if you’re taking it illegally, your doctor needs to know—your health could depend on it. As with any treatment, it’s important to watch for side effects.

With legal changes in store and lots of research coming out, we can probably expect a lot of change, and quickly, when it comes to CBD oil.

See what we know about CBD oil as a potential treatment for lupus, what the side effects are, and what you need to know about the legal status.