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Healing with CBD: How Cannabidiol Can Transform Your Health without the High

Listen as co-authors Eileen Konieczny, RN, and Lauren Wilson discuss why knowledge is power when it comes to the science of cannabis therapeutics and the current consumer landscape.

They address areas of knowledge all CBD consumers should have including: the legal landscape, state medical cannabis programs, how and why CBD works in the body, and much more!

Presented by:

Eileen Konieczny, RN

Medical cannabis expert and US Navy Veteran Eileen Konieczny, RN, found her passion educating patients on safe and effective uses of cannabis-derived medicine from years spent in the healthcare industry. As an oncology nurse for decades and an expert in the administration of medical cannabis, Eileen has seen firsthand its transformative effects for patients, its effects on the lives of families and caregivers, and the sometimes-fraught world of education on the endocannabinoid system. Eileen founded Olive’s Branch, an educational consulting firm, in 2013, to fill this need.

Eileen has fought for medical cannabis legalization nationally and was a recognized leader in the passing of New York’s medical cannabis bill. Eileen has served on the board of directors for the Children’s Health and Research Foundation and currently serves on the board of directors for the Association of Cannabis Specialists. She is Past President of the American Cannabis Nurses Association, a clinical associate in the Society for Cannabis Clinicians and has been involved in licensed medical cannabis operations in New York and Connecticut.

Lauren Wilson

Lauren Wilson is a professional writer, cannabis enthusiast, and food lover. She initially came to the cannabis world in young adulthood and has since developed a far deeper and more meaningful relationship to the plant as a patient seeking a natural option for chronic pain relief. As co-author of Healing with CBD, Wilson hopes to help and support those who may not have considered therapeutic cannabis by offering the knowledge to inspire confidence in its benefits. A graduate of Toronto’s George Brown Chef School in 2008, Wilson is the author of The Walking Dead: The Official Cookbook and Survival Guide and The Art of Eating through the Zombie Apocalypse: A Cookbook and Culinary Survival Guide. She lives in Brooklyn, New York.

Listen as co-authors Eileen Konieczny, RN, and Lauren Wilson discuss why knowledge is power when it comes to the science of cannabis therapeutics and the current consumer landscape. They address areas of knowledge all CBD consumers should have including: the legal landscape, state medical cannabis programs, how and why

Cannabidiol, a Major Non-Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts

Affiliations

  • 1 Bone Laboratory, Hebrew University of Jerusalem, Jerusalem, Israel.
  • 2 Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • 3 Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, Israel.
  • 4 Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.
  • 5 Department of Oral Medicine, Hadassah-Hebrew University Faculty of Dental Medicine, Jerusalem, Israel.
  • 6 Department of Biomedical Engineering, Lund University, Lund, Sweden.
  • 7 Department of Orthopedics, Lund University, Lund, Sweden.
  • PMID: 25801536
  • DOI: 10.1002/jbmr.2513

Free article

Cannabidiol, a Major Non-Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts

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Authors

Affiliations

  • 1 Bone Laboratory, Hebrew University of Jerusalem, Jerusalem, Israel.
  • 2 Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • 3 Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, Israel.
  • 4 Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.
  • 5 Department of Oral Medicine, Hadassah-Hebrew University Faculty of Dental Medicine, Jerusalem, Israel.
  • 6 Department of Biomedical Engineering, Lund University, Lund, Sweden.
  • 7 Department of Orthopedics, Lund University, Lund, Sweden.
  • PMID: 25801536
  • DOI: 10.1002/jbmr.2513

Abstract

Cannabinoid ligands regulate bone mass, but skeletal effects of cannabis (marijuana and hashish) have not been reported. Bone fractures are highly prevalent, involving prolonged immobilization and discomfort. Here we report that the major non-psychoactive cannabis constituent, cannabidiol (CBD), enhances the biomechanical properties of healing rat mid-femoral fractures. The maximal load and work-to-failure, but not the stiffness, of femurs from rats given a mixture of CBD and Δ(9) -tetrahydrocannabinol (THC) for 8 weeks were markedly increased by CBD. This effect is not shared by THC (the psychoactive component of cannabis), but THC potentiates the CBD stimulated work-to-failure at 6 weeks postfracture followed by attenuation of the CBD effect at 8 weeks. Using micro-computed tomography (μCT), the fracture callus size was transiently reduced by either CBD or THC 4 weeks after fracture but reached control level after 6 and 8 weeks. The callus material density was unaffected by CBD and/or THC. By contrast, CBD stimulated mRNA expression of Plod1 in primary osteoblast cultures, encoding an enzyme that catalyzes lysine hydroxylation, which is in turn involved in collagen crosslinking and stabilization. Using Fourier transform infrared (FTIR) spectroscopy we confirmed the increase in collagen crosslink ratio by CBD, which is likely to contribute to the improved biomechanical properties of the fracture callus. Taken together, these data show that CBD leads to improvement in fracture healing and demonstrate the critical mechanical role of collagen crosslinking enzymes.

Keywords: CANNABIDIOL; COLLAGEN CROSSLINKING; FRACTURE HEALING; FTIR; LYSYL HYDROXYLASE; μCT.

© 2015 American Society for Bone and Mineral Research.

Cannabinoid ligands regulate bone mass, but skeletal effects of cannabis (marijuana and hashish) have not been reported. Bone fractures are highly prevalent, involving prolonged immobilization and discomfort. Here we report that the major non-psychoactive cannabis constituent, cannabidiol (CBD), enh …