5 Common Drugs To Avoid When Taking CBD
By Evelyn Valdez
August 27, 2019 in CBD Blog
Table of Contents:
CBD or cannabidiol has been recently popularized due to its numerous medical benefits. The recent passing of the Farm Bill in 2018 has spurred a lot of public interest since CBD provides an alternative to many drugs today. This has caused a significant amount of research to prove CBD’s legitimacy and place in the medical industry.
CBD oil has been used to treat and help many medical illnesses ranging from issues such as pain and inflammation to anxiety. Even though some may doubt CBD’s effectiveness since it can have positive effects in many different ways, many studies have shown that CBD has been both productive and safe to consume.
However, like anything we take into our bodies, there are some unintended risks and side effects when not used properly.
5 Over-the-counter drugs that compete with CBD
Drugs to avoid with CBD
|Drug Name||Working Ingredient||Purpose||Compete with CBD|
|Tylenol||Acetaminophen||Mild pain and fevers||Yes|
|Motrin||Ibuprofen||Pain and fever reducer||Yes|
|Walgreens Wal-Finate||Chlorpheniramine||Allergy relief||Yes|
|CVS Allergy Relief||Chlorpheniramine||Allergy relief||Yes|
Tylonel is one of the most commonly used pain relievers. This over the counter medicine’s main ingredient is acetaminophen. Acetaminophen is used to treat mild pain and fevers.
Acetaminophen conflicts with CBD when taken together. Both are processed through CYP450, making each drug less effective when processed.
Have you heard anyone say take an advil when something is wrong? Advil is one of the most commonly purchased over the counter medicines. The working ingredient in Advil is ibuprofen. Ibuprofen is used to reduce the hormones that cause inflammation.
Ibuprofen is one of the drugs that interacts with the CYP450. When a drug like Advil and CBD are both ingest, they compete to accomplish the same goal, reduce pain.
Motrin is Advil’s direct competitor. Similar to Advil, their working ingredient utilizes ibuprofen. Ibuprofen has been a staple when treating pain. Similar to Advil, Motrin is processed through the CYP450. The efficiency of the CYP450 is diminished when multiple drugs are run through its system. CBD targets a lot of the same problems.
4) Walgreens Wal-Finate Allergy Relief Tablets
Walgreens is one of the largest pharmacy chains in America. Their Walgreens brand allergy relief tablets known as Wal-Finate Allergy Relief Tablets is widely used for common allergies. The working ingredient in their product is chlorpheniramine. Chlorpheniramine is an antihistamine and is processed through the CYP450. By taking CBD with this allergy relief tablet, the effectiveness can be diminished.
5) CVS Health 4-Hour Allergy Relief
Similar to how Advil and Motrin are rivals, CVS is the leading competition with Walgreens. Both powerhouses have their own brand of medicine. CVS Health 4-Hour Allergy Relief uses the active ingredient chlorpheniramine to combat allergies as well. CVS brand allergy medicine is also under the list of drugs that can conflict with CBD when both taken.
The Cytochrome P-450 System
The Cytochrome P450, also known as CYP450, is an enzyme family that can be found in the liver. Enzyme’s purposes are to break down specific things. Cytochrome P450 job is specifically to break down drugs that are introduced into our body.
This enzyme is involved in metabolizing over 60% of drugs.
Doctors use CYP450 to gauge the appropriate dosages of medications based on the processing time it takes for the drugs to be active in the system. They calculate the averages of how fast the drugs are processed through the Cytochrome P450.
If only one drug is being ingested and the CYP450 system is healthy, then these averages provide accurate dosage information. Certain substances or an unhealthy CYP450 system can affect the processing times by either making drugs metabolize slower or faster than they would on their own.
Accurate dosage information depends on what drug is being ingested and if the CYP450 system is healthy and optimal. Different or multiple substances along with an unhealthy CYP450 system can dramatically change the time the specific drug’s processing time.
Scientists recommend to only take in one active drug at a given time in order to optimize your systems efficiency.
Here is a common list of drugs that are taken in our society. You might recognize many of these drugs as either over the counter drugs or prescribed medicines. The following drugs interact with the CYP450 system.
The following drugs interact with the CYP450:
- HMG CoA reductase inhibitors
- Calcium channel blockers
- Antihistamines – allergy relief medicines like CVS / Walgreens Allergy-relief
- HIV antivirals
- Acetaminophen – Tylenol
- Immune modulators
- Beta blockers
- NSAIDs – ibuprofen medicines like Advil / Motrin
- Angiotensin II blockers
- Oral hypoglycemic agents
Why should these drugs be avoided with CBD?
Clinical research has found that CBD inhibits the CYP3A4 and CYP2D6 enzymes. These enzymes are found in liver along with the CYP450. These enzymes can alter the way your body processes drugs. Since CBD may inhibit those enzymes, this can ultimately slow down the metabolization of drugs.
CBD can decrease the lifespan of the prescribed drug when it is induces a CYP enzyme. This thus causes more of the enzyme to be produced.
The CYP450 system metabolizes over 60% of prescribed drugs that enters the system. CBD or cannabinoids may inhibit the enzymes found in the system. This means that prescribed drugs can have a slower time to metabolize, ultimately affecting how your body takes in those drugs.
The reason why this is important is to ensure that you are receiving the optimum benefits of whichever medicine or supplement you are taking. Although taking these drugs while taking CBD is not dangerous or detrimental, taking both can slow or lower the efficiency.
This is counterproductive because you do not want to be taking more drugs or medicine than your body needs and overload your body. For a full list of drugs, check out our CBD drug interactions article which explains everything you need to know about CBD and other drugs.
Whenever something is wrong, you should always discuss with your primary physician whether or not a medicine is right for you. Every medicine interacts with different medicines in different ways. This will help alleviate risks and bad reactions that CBD or any other drugs may have.
Certain drugs compete with the same body systems that CBD interacts with. Avoid stacking these together!
Drug Interactions between cannabidiol and Tylenol
This report displays the potential drug interactions for the following 2 drugs:
- Tylenol (acetaminophen)
Interactions between your drugs
Applies to: Tylenol (acetaminophen) and cannabidiol
Cannabidiol may cause liver problems, and using it with other medications that can also affect the liver such as acetaminophen may increase that risk. You should avoid or limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
Applies to: cannabidiol
Food may affect the absorption and blood levels of cannabidiol. To avoid significant fluctuations in blood levels of the medication, cannabidiol should be taken about the same time each day consistently either with or without food. Consumption of grapefruit and grapefruit juice should be limited, as it may increase the blood levels of cannabidiol. Patients who consume grapefruit or grapefruit juice may require a lower dosage of the medication based on blood levels. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
- Cannabidiol Drug Interactions
- cannabidiol General Consumer Information
- Tylenol Drug Interactions
- Tylenol General Consumer Information
- Drug Interactions Checker
Drug Interaction Classification
|Major||Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderate||Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minor||Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|Unknown||No interaction information available.|
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some mixtures of medications can lead to serious and even fatal consequences.
A Moderate Drug Interaction exists between cannabidiol and Tylenol. View detailed information regarding this drug interaction.