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can i take ibuprofen with cbd oil

5 Common Drugs To Avoid When Taking CBD

By Evelyn Valdez

August 27, 2019 in CBD Blog

Table of Contents:

CBD or cannabidiol has been recently popularized due to its numerous medical benefits. The recent passing of the Farm Bill in 2018 has spurred a lot of public interest since CBD provides an alternative to many drugs today. This has caused a significant amount of research to prove CBD’s legitimacy and place in the medical industry.

CBD oil has been used to treat and help many medical illnesses ranging from issues such as pain and inflammation to anxiety. Even though some may doubt CBD’s effectiveness since it can have positive effects in many different ways, many studies have shown that CBD has been both productive and safe to consume.

However, like anything we take into our bodies, there are some unintended risks and side effects when not used properly.

5 Over-the-counter drugs that compete with CBD

Drugs to avoid with CBD

Drug Name Working Ingredient Purpose Compete with CBD
Tylenol Acetaminophen Mild pain and fevers Yes
Advil Ibuprofen Reduce Pain Yes
Motrin Ibuprofen Pain and fever reducer Yes
Walgreens Wal-Finate Chlorpheniramine Allergy relief Yes
CVS Allergy Relief Chlorpheniramine Allergy relief Yes

1) Tylenol

Tylonel is one of the most commonly used pain relievers. This over the counter medicine’s main ingredient is acetaminophen. Acetaminophen is used to treat mild pain and fevers.

Acetaminophen conflicts with CBD when taken together. Both are processed through CYP450, making each drug less effective when processed.

2) Advil

Have you heard anyone say take an advil when something is wrong? Advil is one of the most commonly purchased over the counter medicines. The working ingredient in Advil is ibuprofen. Ibuprofen is used to reduce the hormones that cause inflammation.

Ibuprofen is one of the drugs that interacts with the CYP450. When a drug like Advil and CBD are both ingest, they compete to accomplish the same goal, reduce pain.

3) Motrin

Motrin is Advil’s direct competitor. Similar to Advil, their working ingredient utilizes ibuprofen. Ibuprofen has been a staple when treating pain. Similar to Advil, Motrin is processed through the CYP450. The efficiency of the CYP450 is diminished when multiple drugs are run through its system. CBD targets a lot of the same problems.

4) Walgreens Wal-Finate Allergy Relief Tablets

Walgreens is one of the largest pharmacy chains in America. Their Walgreens brand allergy relief tablets known as Wal-Finate Allergy Relief Tablets is widely used for common allergies. The working ingredient in their product is chlorpheniramine. Chlorpheniramine is an antihistamine and is processed through the CYP450. By taking CBD with this allergy relief tablet, the effectiveness can be diminished.

5) CVS Health 4-Hour Allergy Relief

Similar to how Advil and Motrin are rivals, CVS is the leading competition with Walgreens. Both powerhouses have their own brand of medicine. CVS Health 4-Hour Allergy Relief uses the active ingredient chlorpheniramine to combat allergies as well. CVS brand allergy medicine is also under the list of drugs that can conflict with CBD when both taken.

The Cytochrome P-450 System

The Cytochrome P450, also known as CYP450, is an enzyme family that can be found in the liver. Enzyme’s purposes are to break down specific things. Cytochrome P450 job is specifically to break down drugs that are introduced into our body.

This enzyme is involved in metabolizing over 60% of drugs.

Doctors use CYP450 to gauge the appropriate dosages of medications based on the processing time it takes for the drugs to be active in the system. They calculate the averages of how fast the drugs are processed through the Cytochrome P450.

If only one drug is being ingested and the CYP450 system is healthy, then these averages provide accurate dosage information. Certain substances or an unhealthy CYP450 system can affect the processing times by either making drugs metabolize slower or faster than they would on their own.

Accurate dosage information depends on what drug is being ingested and if the CYP450 system is healthy and optimal. Different or multiple substances along with an unhealthy CYP450 system can dramatically change the time the specific drug’s processing time.

Scientists recommend to only take in one active drug at a given time in order to optimize your systems efficiency.

Here is a common list of drugs that are taken in our society. You might recognize many of these drugs as either over the counter drugs or prescribed medicines. The following drugs interact with the CYP450 system.

The following drugs interact with the CYP450:

  • Steroids
  • HMG CoA reductase inhibitors
  • Calcium channel blockers
  • Antihistamines – allergy relief medicines like CVS / Walgreens Allergy-relief
  • Prokinetics
  • HIV antivirals
  • Acetaminophen – Tylenol
  • Immune modulators
  • Benzodiazepines
  • Antiarrhythmics
  • Antibiotics
  • Anesthetics
  • Antipsychotics
  • Antidepressants
  • Anti-epileptics
  • Beta blockers
  • PPIs
  • NSAIDs – ibuprofen medicines like Advil / Motrin
  • Angiotensin II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas

Why should these drugs be avoided with CBD?

Clinical research has found that CBD inhibits the CYP3A4 and CYP2D6 enzymes. These enzymes are found in liver along with the CYP450. These enzymes can alter the way your body processes drugs. Since CBD may inhibit those enzymes, this can ultimately slow down the metabolization of drugs.

CBD can decrease the lifespan of the prescribed drug when it is induces a CYP enzyme. This thus causes more of the enzyme to be produced.

The CYP450 system metabolizes over 60% of prescribed drugs that enters the system. CBD or cannabinoids may inhibit the enzymes found in the system. This means that prescribed drugs can have a slower time to metabolize, ultimately affecting how your body takes in those drugs.

Final thoughts

The reason why this is important is to ensure that you are receiving the optimum benefits of whichever medicine or supplement you are taking. Although taking these drugs while taking CBD is not dangerous or detrimental, taking both can slow or lower the efficiency.

This is counterproductive because you do not want to be taking more drugs or medicine than your body needs and overload your body. For a full list of drugs, check out our CBD drug interactions article which explains everything you need to know about CBD and other drugs.

Whenever something is wrong, you should always discuss with your primary physician whether or not a medicine is right for you. Every medicine interacts with different medicines in different ways. This will help alleviate risks and bad reactions that CBD or any other drugs may have.

Certain drugs compete with the same body systems that CBD interacts with. Avoid stacking these together!

Can CBD Oil Be Taken with Ibuprofen? [What the Science Says]

Pain and inflammation are part of life. If you’re someone who struggles with pain often, then ibuprofen is probably a good friend of yours. In recent times, however, more and more folks are turning to CBD oil to help manage pain in a more natural way.

This raises the question – can CBD oil be taken with ibuprofen?

Let’s take a look…

CBD Oil vs. Ibuprofen: How Does Ibuprofen Manage Pain?

Ibuprofen is one of the most common non-steroidal anti-inflammatory drugs (NSAIDs), first discovered in 1961. Today, it’s an active ingredient in numerous over-the-counter pain-relief drugs, including household names like Motrin and Brufen. Ibuprofen is very effective at eliminating most forms of pain that result from inflammation. It also works well as a fever reducer.

Ibuprofen works by blocking a specific type of hormone known as prostaglandin. Unlike normal hormones, prostaglandins are not secreted by any kind of gland. Rather, they form via chemical reaction at the site they’re needed. This is typically a site in which there has been infection or tissue damage (hence the resulting pain, inflammation, fever, etc).

Ibuprofen limits the number of enzymes produced by cyclooxygenase-2 (COX-2). This results in decreased prostaglandin release when the body experiences injury, leading to lowered inflammation and pain.

It’s important to note that ibuprofen comes with some serious potential side effects, especially when taken in large quantities. Some of these include heartburn, dizziness, high blood pressure, stroke, ulcers (stomach bleeding), and heart attack.

What Makes CBD Different?

Cannabis has been consumed for centuries to help alleviate pain, and now scientists are aiming to find the link between cannabinoids and their anti-inflammatory and analgesic (pain-relieving) potential.

As one of more than 100 cannabinoids found inside the cannabis plant, CBD offers many potential health benefits without causing users to feel “high.” The primary difference between CBD and ibuprofen is the way in which they interact with pain response pathways. CBD binds to CB1 and CB2 receptors, while ibuprofen blocks the COX-2 from producing extra prostaglandins.

The analgesic mechanism of CBD is complex and not as well understood as that of ibuprofen. However, it appears to offer pain relief by inhibiting the action of neurotransmitters.

The analgesic mechanism of CBD is complex, and not as well understood as that of ibuprofen.

According to a 2018 publication in Frontiers of Pharmacology, cannabinoids (like CBD) have an inhibitory effect on neurotransmitters and neuropeptides that are involved in the “activation of descending inhibitory pain pathways, [as well as] reduction of neural inflammation.”

So, as you can see, the differences between CBD and ibuprofen for pain relief are quite distinct. Of course, ibuprofen and CBD are often not enough by themselves to combat pain completely. This leads many to want to use the two drugs in combination. But is using ibuprofen and CBD oil together safe?

How Does CBD Interact with Ibuprofen?

Currently, not much is known about how CBD could interact with other medications – including ibuprofen. More research needs to be done, but research has shown that CBD poses inhibitory action on some enzymes that galvanize drug metabolism.

This means that the risk of experiencing adverse side effects linked to ibuprofen use may increase when the drug is used in conjunction with CBD.

When looking at CBD drug interactions, there are two basic categories:

  • Those that can create a dangerous interaction and therefore, should never be used in conjunction with CBD
  • Those that require you to be cautious when using the two together

Ibuprofen falls into the second category – you should be cautious when using it together with CBD. Since the interaction between the two may either increase or decrease how quickly liver enzymes are able to break down drugs, the overall effects of the ibuprofen may be reduced or intensified.

Dosing and Timing Could Influence How CBD Interacts with Ibuprofen (And Other NSAIDs)

The time at which you take both CBD and ibuprofen may influence how the two drugs interact in your body. This is because spacing out doses of medication helps to reduce the workload on the liver.

For instance, depending on a drug’s half-life (and the dose of the drug), it has the potential to inhibit liver enzymes for a variable timeframe. Therefore, liver enzymes could regain sufficient function by the time the second drug (i.e. CBD) is taken.

The risk of experiencing adverse drug interactions may be lower if you consume ibuprofen and CBD at different times of the day.

The dosage used may also have an effect on any potential interaction of ibuprofen with CBD. When large amounts of CBD and ibuprofen are used together, there may be an increased risk of danger (such as increased stomach bleeding). Some medical experts have speculated that taking low amounts of CBD doesn’t seem to affect the way the liver metabolizes ibuprofen.

Of course, it’s worth noting that everyone responds to drugs differently. Some individuals may be sensitive to certain substances, while others may have little to no reaction. Ultimately, how the body processes medication – and the effect it has – is very much influenced by genetics, body size, age, and so on.

Final Thoughts on CBD and Ibuprofen

While taking low amounts of ibuprofen and CBD will likely not produce severe adverse effects on the body, more research needs to be conducted on the topic. Due to interaction with enzyme activity, there is the potential that CBD may either intensify or reduce the effects of ibuprofen.

Ultimately, it’s best to consult with a doctor or healthcare provider before using CBD oil in conjunction with ibuprofen. They will be able to help you decide whether it’s safe to use CBD oil, and may also be able to offer medical advice regarding the dosage of CBD oil that may be effective without causing any adverse effects.

A lot of people take CBD oil with ibuprofen for pain relief. But is it safe? Here, we explain everything you need to know.