Best CBD Oil For Seizures – Top 5 Wonderful Options
Every day we are bombarded by external stimuli – lights, sounds, traffic, noise, you name it. And, our body processes all of these stimuli through the central nervous system coordinating the signals into a symphony of sounds and visions that make sense to us.
Our central nervous system coordinates all of this stimuli through communication with electrical impulses transmitted through neurons, which are cells that make up the brain. This system usually functions quite well, but when it doesn’t, that is when a seizure can happen. A seizure is an uncontrolled electrical impulse in the brain. It is literally a brainstorm of electrical activity.
CBD for Epilepsy
CBD can help treat various health problems, with the best CBD oil can be found here. While many drugs can treat epilepsy, none are known to prevent its development. A third of people with epilepsy remain resistant to their medications. This leaves them open to increased risk of sudden unexpected death from epilepsy-related seizures or impairments in psychosocial, behavioral, and cognitive functions. This resistance to traditional medications makes CBD products very appealing as an alternative treatment modality.
The interaction between CBD and other epileptic medications is unknown and may be responsible for the elevated liver enzymes seen in some studies of Epidiolex  (FDA’s approved CBD drug for epilepsy). However, such adverse effects were not severe and precautions were issued with recommendations to monitor the liver enzymes and concurrent medication levels while using CBD. Otherwise, CBD is generally considered safe, non-psychoactive, with few side-effects.
Why is it better?
- Vegan and gluten-free
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The Lineup At A Glance
- GMO free
- Natural flavoring
- CO2 extraction
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- Wide range of products
- Zero THC
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- CO2 extracted
- Full spectrum oil
- MCT oil derived from coconuts
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- GMO free
- Zero pesticides
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Top 5 Best CBD Oil for Seizures Reviews 2020
Spruce is a family-owned business that offers high quality full spectrum hemp oil made without pesticides and zero high.
- Vegan free
- Gluten free
- Cost higher than average
- Only two potencies to choose from
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The products are all third-party lab tested and certified for purity of ingredients. It is unique in that it uses an alcohol extraction method rather than CO2, a method just as safe and effective. Spruce have also rated as one of the best CBD brands for several health issues.
The CBD is extracted from hemp that has been bred and cultivated for over 200 years in the U.S. It is grown in Kentucky and North Carolina.
Spruce products are full-spectrum meaning you get the benefits of all the cannabinoids, the terpenes, vitamins and natural flavorings of the original plant it came from. This means you benefit from the entourage effect, a synergistic blending of chemicals that heightens the actions of each other.
The 30 ml peppermint flavored vials come in two strengths: 25 mg CBD per ml (750 mg total) and 80 mg of CBD per ml (2,400 mg total).
The company also provides third-party testing of all of its products guaranteeing safety and quality.
CBD Pure Oil
CBD Pure offers affordable products that offer great results in different dosage options.
- GMO free
- Natural flavoring
- CO2 extraction
- Only 2 forms of products
- Few flavor options
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This organic farm began in 2016 in Colorado with a mission to provide the best CBD product on the market. The farm does not use any pesticides or herbicides on it’s organic ranch.
They third-party test all of their products to guarantee freshness and purity to their customers and even provide a downloadable version of their test to any given location.
They are affordable and even offer coupons to help defray expenses. These coupons can be applied at check-out.
The natural flavoring is due to the fact that all of the plant residue was removed during CO2 extraction. It is noticeable in the lack of green tint to the oil and is tasteless in the softgels.
To prove confidence in their product, CBD Pure offers a 100% guarantee on all of its products so that if you are not entirely satisfied you can return the product and get your money back within 90 days.
Joy Organics – Best CBD oil for seizures
The company prides itself on its transport to all U.S. states and in its freedom from harsh metals, THC and gluten. It is also organic and Farm Bill compliant.
- GMO free
- Wide range of products
- Zero THC
- Unclear sourcing
- Not recommended for vegans
- Does not offer international shipping
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Joy Organic uses only phytocannabinoid-rich hemp that contains a range of 112 cannabinoids! Most of the CBD oils have some THC in them, but CBD Pure does not have a trace of it in their products. However, the user may still benefit from the entire entourage effect of all 112 cannabinoids!
The products go through a testing process whereby a Certificate of Quality Assurance and a Certificate of Analysis are generated by both in-house testing and a third-party lab. Both of these are indicators of purity and standard of quality.
Joy Organic prides itself on using only the finest U.S. grown hemp. Standards at American hemp farms are higher than those in other countries.
The oil products come in four flavors, orange, tranquil, natural and mint. Along with the four flavors come four different potentcies, 250, 500, 1000 and 1500 mg per bottle. The oil itself undergoes a process to make it more bioavailable, a technique called nanotechnology emulsion which involves breaking down the molecule into smaller, more digestible components.
The company does not charge for its shipping fees, thus saving the customer valuable money.
This innovative company, which started in 2015, hosts a wide variety of products which it sells nationally and internationally.
- CO2 extracted
- Full-spectrum oil
- MCT oil derived from coconuts
- Important information not readily available
- Returns are not convenient
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CBDfx extracts its oils from hemp grown in Europe or Kentucky where it is then shipped to southern California for further processing.
CBDfx uses organic farming techniques and CO2 extraction to guarantee the finest CBD oils it can produce. CO2 is widely considered the safest option for extraction of hemp.
Being full-spectrum, you are guaranteed the entourage effect so vibrant in the function of CBD. Full-spectrum means you have the advantage of the terpenes, flavonoids and all the cannabinoids in the oil.
The product line is widely diverse from those supplements made for pets to those for the rest of us like tinctures, oils, drinkable shots, sublingual strips in fun flavors, and capsules.
Penguin CBD is organically grown in the U.S. on an environmentally conscious farm with no pesticides and produces both broad-spectrum and isolate forms of product.
- Broad-spectrum and isolate
- Variety of flavors
- Variety of products
- Limited strength availability
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Penguin CBD was founded in 2019 in Oregon topping numerous “best of” lists and gathering acclaim from reputable sources.
They use a broad-spectrum oil meaning you gain all the entourage effects of the cannabinoids, minus the THC. The gummies contain only isolate forms of CBD. CBD isolate contains only CBD, thus, a pure dose of CBD can be administered without the terpenes and other cannabinoids. The softgels also come in isolate form.
The oils come in four flavors and three strengths. Natural, Strawberry, Cookies and Cream, and Mint top the flavor list. The strengths come in 250, 600 and 1000 mg. The supplements come in doses of 15mg-750 mg per 30-tablet bottle.
There are a wide variety of products to choose from including tinctures, oils, creams, gummies, bath bombs, edibles and capsules.
Does CBD Oil Help with Seizures?
The current therapy for seizure control fails to control seizures in 30-40% of patients  , leaving an unmet need for other viable treatment options for this disorder. Not only is there a high failure rate, but the side-effects to classical seizure treatment is often felt to be worse than the seizures themselves. It is no wonder that many people have turned to CBD as a potential, alternative treatment option for epilepsy and seizures.
In research published in Epilepsy & Behavior  , it was found that those using CBD had reduced seizure frequency and its side-effect profile in only 12 weeks, with the maintenance of results stretching into 24 and 48 weeks. This research study used oil void of THC.
Research has shown the use of CBD oil to decrease the frequency of treatment resistant epilepsy  with Gestalt syndrome by 20% while the rate of decrease in undifferentiated epilepsy is less clear.
How Does CBD Oil Stop Seizures?
CBD restores normal brain rhythms. It does not do this by a direct effect on cannabinoid receptors, however. It acts via the endocannabinoid system. CBD antagonizes the GPR55 receptor at excitatory synapses  in the brain and inhibits the chemical messengers thus calming seizure activity. The GPR55 receptor is one of the endocannabinoid receptors involved in CBD communication between cells and are part of the endocannabinoid system.
CBD desensitizes TRPV1 channels. The TRPV1 channels determine how your body experiences pain and are located throughout your central nervous system and brain. People who have epilepsy have more TRPV1 receptors in the temporal lobes of their brains than those who do not have epilepsy.
CBD inhibits nucleotide transporters reducing adenosine updates. In the brain, adenosine is a CNS depressant, an inhibitory neurotransmitter. It is essential for the proper functioning of every cell in the body. Research shows us that adenosine receptors are powerful for regulating seizures in epilepsy  .
CBD Treatment for Seizures
The two main cannabinoid treatments for seizure are THC and CBD. The Food and Drug Administration (FDA) only recognizes Epidiolex, a purified CBD isolate, as an approved form of treatment for two forms of epilepsy, Dravet Syndrome & Lennox Gastaut Syndrome (LGS). Gastaut Syndrome and Dravet Syndrome  are each a form of epilepsy where using CBD has been shown to make a significant positive difference for many people.
Gastaut Syndrome and Dravet Syndrome are severe refractory forms of epilepsy that begin in childhood and are resistant to most treatment. Current available treatments fail to control seizures in most cases thus making the identification of new medications necessary.
Some research has shown CBD-rich extracts performed better than purified CBD  in treatment resistant epilepsy. Patients using the extracts used a lower dose than that for purified CBD and reported fewer side-effects. This study  concluded that CBD extracts had a better therapeutic profile than did purified CBD in treatment resistant epilepsy.
According to conflicting research, pure CBD products may be the ideal candidate for treatment resistant epilepsy  therapy. It is believed to calm seizures by normalizing brain rhythms through a cascade of events. The true mechanism remains unclear  , however, and some of the research is contradictory.
Epidiolex is pure CBD, with no THC added. CBD has no “high” associated with it, as THC does. FDA currently allows CBD products for sale with up to 0.3% THC in it as a full-spectrum product. Research shows THC can have both seizure-promoting  and anti-seizure activity making its use as a drug for seizure control more conflicting.
CBD Oil for Non-Epileptic Seizures
Epilepsy is the most common pathology of the brain  accounting for 1% of the worldwide burden for this disease. Diagnosis can be difficult and would be made easier if a reliable set of biomarkers for this disease could be agreed upon. Though seizures are characteristic of all types of epilepsy other common symptoms may include muscle jerking, staring, loss of consciousness, weakness, and anxiety.
Animal research has shown CBD is effective at reducing seizures regardless of the cause  or type of epilepsy making CBD oil attractive for possible use in non-epileptic seizures such as seizures caused by increased inflammation or drugs. Oxidative stress can also stimulate seizure activity.
CBD has been shown to reduce inflammatory mediators, thus reducing seizure risk. CBD has antioxidant properties, which also aid in the alleviation of oxidative-stress-induced seizure activity.
Furthermore, CBD may reduce free radical generation and metabolism. Free radicals can build up in cells and can cause damage. Most of the harmful effects of oxygen are due to free radical generation.
How to Use CBD Oil for Seizures
CBD oil is a carrier medium mixed with CBD and an oil such as olive, coconut, or other indigestible oil and can also contain other endocannabinoids depending on whether you buy isolated, broad, or full-spectrum products.
Choosing the right oil can be critical to your success in alleviating your seizures. CBD products come in isolate forms devoid of THC and other cannabinoids except for CBD, or as full-spectrum CBD products that contain all the cannabinoids and makes full use of the endocannabinoid system, or as a broad-spectrum CBD product, which contains all the cannabinoids except for THC.
CBD oil used orally is best absorbed by placing under the tongue and holding it there for a time to allow maximal absorption and avoiding the first-pass metabolism through the gastrointestinal tract. There is a large vein located just under the tongue where absorption can start immediately.
CBD products also come in various edible forms or can be smoked in a vape cartridge. It might be noted that FDA has not cleared using CBD for oral consumption  despite legalizing its sale and despite a statement from the World Health Organization that the consumption of CBD is safe and not subject to addictive properties.
CBD Oil Dosage for Seizures
Because of the FDA ruling, it is not legal to propose dosages for CBD where we are not dealing with an FDA-approved medical condition attributed to a drug. The only drug to receive FDA approval for the treatment of epilepsy is Epidiolex, a plant-derived source of pure CBD.
Each CBD product contains a different concentration. Read the product instructions to assure you are taking it properly. Talk with a doctor or health professional if you have questions about how to take CBD for specific conditions and, especially if there are any drug-nutrient concerns.
Of interest, in the Epidiolex studies, most patients were treated with doses of CBD between 20-30 mg/kg/day. Establishing dosages for CBD oil that is effective has been challenging due to the lack of human clinical trials in this area. The lack of human trials can historically be blamed on its legality, the difficulties in gaining funding, and limitations of state-to-state transport. Some of this legal red tape is coming to an end with the legalization of hemp and the liberalization of the sale of CBD.
Hemp Oil for Seizures
Hemp derived extract was given to 138 patients for epileptic seizures  . Sixty-eight percent of the study respondents reported decreased seizure severity or frequency from the effects of CBD. About 2/3 reported other effects of CBD such as better sleep and improved alertness. Adverse events were reported by 22% and included diarrhea, fatigue, and increased seizures.
Cannabis oil may have unwanted levels of THC in it, which, in some studies, has precipitated seizures and caused increased anxiety. Hemp derived oil comes from the agricultural hemp plant, a plant different in composition than the cannabis plant since hemp is bred to contain minimal amounts of THC.
Best CBD Oil for Epilepsy
The research to date points to using CBD as the preferred cannabinoid in the treatment for epilepsy. The addition of THC may increase the risk of seizures and may invoke side-effects not seen with pure CBD. The best CBD oils for epilepsy are the isolates and the broad-spectrum oils, which contain no THC and are the closest in structure to Epidiolex, keeping in mind that more study is needed and this area is still controversial.
Frequently Asked Questions
Although the World Health Organization  has cleared CBD of any serious side-effects, clinical trials have shown that as many as 20% of those using CBD may experience low blood pressure, fatigue, dizziness, or diarrhea. CBD should not be used in pregnancy since animal studies have shown developmental delays and fetal abnormalities. Human studies have not been done in this area.
In some cases, yes; Some studies  have shown users of whole hemp-extracted oils had more seizures than prior to using these oils. Users of CBD oils are recommended to keep a symptom diary not only for dose adjustments but to track any adverse events or increase in seizure activity. More clinical trials in this area are needed.
The optimal strains of cannabis for seizures are the ones highest in CBD, such as Charlotte’s Web, Cannatonic, Purple Urkle, Grape Ape, Haleigh’s Hope, and Harlequin.
Many studies show possible anti-seizure activity by CBD. Although the exact mechanism is unclear, its effects appear to be multifaceted acting on a number of different endocannabinoid targets including the GPR55 and TRVP receptors.
Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here
- EPIDIOLEX is the first and only FDA‑approved prescription cannabidiol (CBD). Available from: https://www.epidiolex.com/
- Jerzy P Szaflarskiab, Elizabeth Martina Bebinab, Gary Cutter, et al. 2018. Cannabidiol improves frequency and severity of seizures and reduces adverse events in an open-label add-on prospective study. Available from: https://www.sciencedirect.com/science/article/pii/S1525505018304736
- Siri Shaqra, Steven Solum. 2020. Does CBD decrease the frequency of seizures in adults with epilepsy refractory to usual anti-seizure medications?
- Kathryn Nichol, Colin Stott, Nicholas Jones, Royston A Gray, Michael Bazelot, Benjamin J Whalley. 2019. The proposed multimodal mechanism of action of cannabidiol (CBD) in epilepsy: modulation of intracellular calcium and adenosine-mediated signaling (P5.5-007). Available from: https://n.neurology.org/content/92/15_Supplement/P5.5-007#:
About Kathy Shattler, MS, RDN
Kathy Shattler has been a Registered Dietitian for over 25 years and currently runs her own Telehealth Clinic while freelance writing in her spare time. She graduated with a Master of Science degree in Human Nutrition from Michigan State University and has a plethora of experience in both clinical nutrition as well as public health. She has been deemed a trailblazer in her profession and continues to strive for excellence in public health education in integrative medicine and in her professional writing career.
Based on current literature on CBD’s effects on seizure, dosage, and use of CBD oil. We have found the best CBD oil for seizures choices 2021 .
CBD Oil for Seizures & Epilepsy: How Cannabis Oil Can Stop Seizures
According to the Michigan Epilepsy Foundation, 1% of Americans suffer from some form of epilepsy — a recurring neurological disorder known for frequent, often unprovoked seizures.
Epilepsy compromises all aspects of a person’s daily life. The violent tremors caused by a seizure attack can put the individual in grave danger, not to mention that people with epilepsy are also prone to suffer from sleep issues, migraines, anxiety disorders, and depression.
Of all epilepsy forms, up to 40% is drug-resistant, meaning the patient doesn’t react to Antiepileptic Drugs (AEDs). For these patients, AEDs are simply ineffective, or the side-effects are too severe to allow for continuous treatment.
As a result, many turn to natural resources to help manage their condition. CBD oil is one promising option whose antiepileptic effects have been thoroughly studied by scientists.
In this article, I’ll cover the potential benefits of CBD oil for epilepsy and seizures — and share the top brands I trust when it comes to manufacturing high-quality CBD oil.
Best CBD Oil Brands for Epilepsy & Seizures
There are lots of different CBD companies trying to make their name in the market with their CBD oil. Some brands provide high-quality products and can back up their claims with third-party lab reports. In contrast, others tend to take advantage of unaware consumers with lots of fancy buzzwords and unrealistic promises.
If you want a clean and potent CBD oil, you need to find a manufacturer that makes organic products with proper quality assurance.
Don’t have time for that? Don’t worry — I did the research for you.
Here are my top 3 brands that make premium CBD oil for different types of consumers.
1. Royal CBD
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- Royal CBD comes from organic hemp grown on American farms
- The company employs CO2 extraction so their extracts are clean and safe
- Their CBD oil comes in three different strengths: 250 mg, 500 mg, 1000 mg, and 2500 mg
- Up to 83.3 mg of CBD per mL
- Hemp extract is suspended in premium MCT oil
- Every batch of product has been tested by a third-party laboratory
- No vapes or vape oils available (yet)
- The price is on the higher end, although justified
My Thoughts on Royal CBD:
Royal CBD is a premium brand that uses only high-quality ingredients in their product lineup. The company’s product range includes every basic CBD format, from sublingual drops to gummies and capsules.
The oil and capsules are full-spectrum, meaning they also contain other cannabinoids and terpenes from hemp. Gummies, on the other hand, contain 99% pure isolate.
The Royal CBD oil comes in three different potencies: 250 mg, 500 mg, 1000 mg, and 2500 mg. The strongest option gives you 83 mg of CBD/mL. I would recommend this variant for stronger symptoms. Those who need noticeably higher doses of CBD may find the weaker bottles cost-prohibitive.
If you don’t want to measure out the oil each time you need CBD, you may switch to Royal capsules. Each softgel carries 25mg of full-spectrum cannabidiol in an easy-to-swallow form.
All Royal CBD products are sent to third-party laboratories for content analysis — checking the potency of CBD as well as purity levels.
2. Gold Bee (Best Organic)
- Unique product selection
- Non-GMO, Colorado grown hemp
- Full-spectrum CBD
- Extracted with CO2
- Up tp to 1200 mg of CBD per bottle (40 mg/mL)
- Sweetened with organic honey
- Third-party lab tested for potency and purity
- No high-strength oils
- Not available in-store
My Thoughts On Gold Bee:
Gold Bee specializes in all-organic CBD products, including full-spectrum CBD oil, high-potency CBD capsules, gummies, and delicious honey sticks. The company’s CBD oil is available in one potency option, packing 1200 mg of CBD per bottle.
This concentration translates into 40 mg of CBD in each milliliter. The oil has been suspended in premium-grade MCT oil and infused with natural terpenes to enhance the synergy between CBD and other compounds in hemp. There are two flavors available: natural and kiwi. The kiwi flavor is sweetened with organic honey, which only adds to the product’s value.
I’ve been taking the Gold Bee CBD oil for 30 days, using the dosage based on the recommended serving size. At first I was skeptical because I got used to higher doses in my routine — low doses could hardly calm my nervous system.
To my surprise, 1 mL a day split into two doses was enough to boost my resistance to stress and the outside stimuli. After two weeks, I slightly decreased the dosage and was still getting pretty good results. This was the first time a potency lower 1500 mg lasted more than 1 month for me.
- CBDPure products come from organic hemp grown in Colorado
- The company uses CO2 extraction
- All products are tested by 3rd-party laboratories for potency and purity
- Available in 60 mL bottles
- 100% Satisfaction Guaranteed program — you can send your order back within 90 days for a full refund
- CBDPure only sells CBD oil and capsules
- The oil is slightly less potent than Royal CBD
My Thoughts on CBDPure:
CBDPure was established in 2016 by a group of cannabis advocates from Colorado. The company has a simple mission, which is to make premium-quality CBD oils from organic hemp.
Although CBDPure has a very narrow product range — offering only CBD oil and capsules — they seem to have perfected these products. All extracts from CBDPure are obtained using supercritical CO2 and tested in a certified laboratory for quality assurance.
The oil isn’t as potent as the one offered by Royal CBD, but if you benefit from lower doses, their 60-mL bottles will get you supplied for months to come. Their oils are a good option for people who use CBD for general health care or to ease mild symptoms.
If you’re looking for something potent, try CBDPure capsules — each softgel is infused with 25 mg of full-spectrum CBD for easier dosing and extra convenience.
CBDPure has a Satisfaction Guarantee program, so in case you ended up unsatisfied with your purchase, you can get a full refund if you send the order back within 90 days.
- CBDistillery uses Colorado-grown hemp
- Their products are available as full-spectrum or isolate
- They have an impressive product selection
- Each batch is sent to a 3rd-party lab for content analysis
- Very affordable
- Their hemp isn’t organic
My Thoughts on CBDistillery:
CBDistillery is a company founded in Denver, Colorado. They’ve been offering high-quality CBD oil products for over 5 years now. One of the driving forces behind the brand is to manufacture CBD oil for every budget and promote research and education among consumers all over the country.
CBDistillery has many different forms of CBD, from sublingual tinctures to capsules, gummies, topicals, and vapes. Their CBD oil is available as ‘full-spectrum’ or isolate.
These oils come in two different sizes — 15 mL and 30 mL
The potency of the 15 mL bottle ranges between 150–1,000 mg of CBD. The 30 mL bottle offers from 2,500–5,000 of total CBD.
With such a wide potency range, CBDistillery oils may suit both novice and experienced consumers alike. The only downside to the company’s product range is that they’re not made with organic hemp.
However, this becomes understandable once you consider the price of CBDistillery products. The company may not sell the best CBD oil on the market, but they offer the best CBD products in this price range.
What is CBD Oil?
CBD oil is a cannabis extract with high concentrations of CBD. This product can be sourced from both marijuana and hemp, two members of the cannabis plant family.
It’s worth noting that marijuana-derived CBD oil contains higher levels of THC, the psychoactive cannabinoid responsible for getting users “high.”
CBD oil from hemp has only trace amounts of THC — typically below 0.3% — and thus can’t produce any psychoactive effects.
That’s because CBD is non-psychoactive per se.
CBD oil reportedly has a plethora of health benefits. However, the best-documented evidence thus far comes from epilepsy trials.
Does CBD Oil Work for Seizures?
The earliest studies proving the effectiveness of cannabis compounds in the treatment of convulsions came from animal research from the 1970s. The researchers analyzed the anticonvulsant properties of both THC and CBD oils, concluding that both extracts had substantial effects on mice.
Early experiments reported that the seizure activity might in part, be regulated by the endocannabinoid system — an interconnected network of cannabinoid receptors and neurotransmitters called endocannabinoids.
The Mechanism Behind the Antiepileptic Effects of CBD
The endocannabinoid system works to keep the body in a state of equilibrium, maintaining chemical balance and controlling biological functioning, from appetite to motor control, sensory perception, sleep, and inflammation.
It sends signals to various bodily systems through its chemical messengers called endocannabinoids to do this. These molecules bind to the cannabinoid receptors which occur in the brain and throughout the body. By doing so, endocannabinoids help the endocannabinoid system to maintain healthy functioning of an individual.
Once endocannabinoids have done their work, they get broken down by enzymes to prevent overaccumulation.
As a cannabinoid, CBD is almost identical in its chemical structure as endocannabinoids produced by your body. When you ingest CBD, it’s able to affect cannabinoid receptors on top of acting on several other pathways.
While scientists still don’t know exactly how CBD oil works for seizures, they’ve observed the following interactions which may explain the positive effects:
- Endocannabinoids are neuroprotectants, lowering the risk of seizures caused by neurotoxicity. When a person ingests CBD, they introduce more cannabinoids to their system—potentially improving the performance of the endocannabinoid system with their neuroprotective properties.
- The endocannabinoid system also modulates neuroexcitation, a process that may trigger seizures. A properly functioning endocannabinoid system, bolstered by additional cannabinoids from CBD oil, may prevent the overexcitation of neurons.
- CBD is also an anti-inflammatory agent. Seizures may be triggered, or their frequency may be increased by brain inflammation. By curbing neuroinflammation, CBD may reduce both the severity and frequency of seizure attacks.
Now, let’s elaborate on the scientific findings regarding the antiepileptic properties of CBD oil.
What the Research Says
The majority of specific case studies from the late 1990s, and the early 2000s focused on the effect of THC/CBD solutions on epilepsy. Due to the psychoactive nature of THC, the eyes of modern medicine turned to CBD.
In June 2018, the FDA approved the first CBD-based drug. The oral spray, called Epidiolex, contains 99% pure CBD. It’s used for treatment-resistant forms of childhood epilepsy — such as Lennox-Gastaut syndrome and Dravet syndrome.
Both diseases begin during early childhood and often lead to delayed or poor development of the child’s motor skills, language, intellectual aptitude, and the ability to communicate with others.
Before receiving the FDA’s approval, Epidiolex went through three randomized, double-blind, placebo-controlled clinical trials examining 516 patients with either syndrome. When administered along with other medications, Epidiolex successfully reduced the participant’s frequency of seizures compared to the placebo group. Besides, CBD improved other associated symptoms for the participants, such as sleep and anxiety.
Currently, Epidiolex can be officially used to treat these two types of epilepsy. However, recent research suggests that CBD may help relieve other forms of this disease as well.
For instance, a 2015 study analyzing the reports from Epidiolex patients from 11 epilepsy centers across the country showed that the frequency of seizures decreased by 36.5% after a 13-week treatment.
All subjects had severe, childhood-onset forms of epilepsy, including Lennox-Gastaut syndrome and Dravet Syndrome. The researchers started with a dose of 2–5 mg/kg per day and gradually increased it to 25–50 mg/kg per day.
Can You Develop a Tolerance to CBD Oil for Seizures?
People who have treatment-resistant epilepsy tend to experience a “honeymoon” period upon switching to a new therapy. In other words, they stop feeling the effects of their new treatment after a few months. In late 2018, scientists observed that the same pattern might apply to CBD treatment.
The study examined nearly 100 patients, of which about one-third developed a tolerance to CBD. The tolerance showed up about seven months after they began the therapy. From then on, they had to increase the dose to maintain the effects. When the dose was higher, nearly half of the examined sample experienced their previous response level.
The good news, though, is that for two-thirds of participants, the CBD proved effective in the long run.
How to Use CBD Oil for Epilepsy
CBD can take many forms. Epidiolex, the only approved CBD treatment for epilepsy, is an oral solution containing 99% pure CBD.
If you want to use CBD in a more natural form to see how it works for your symptoms, you may try the following formats:
- Sublingual drops: The most common form of CBD. The drops are administered via a dropper under the tongue, where they get absorbed through special membranes into the bloodstream. Sublingual drops provide the most consistent blood absorption rates according to studies.
- Capsules: CBD capsules are sold as pills and softgels. You just swallow them like any other pill. They offer a fixed dose of CBD in each serving, which makes dosing easier than sublingual drops, not to mention you can avoid any natural hemp taste.
- Vape oils: this form of CBD is inhaled through a vaporizer or vape pen. Many people prefer vape oils over other products because they find the act of inhalation relaxing, and they like the flavoring of vape oils. But most importantly, vape oils deliver more CBD to your system than any other consumption method.
CBD Oil Dosage for Epilepsy & Seizures
The dose-finding process will vary between patients. As with every new substance, a conservative approach and slow dosage increase will minimize the chance of severe side effects and leave room for adjusting the dose from the starting point.
For each individual, the optimal CBD dosage will depend on the following:
- CBD concentration
- Cannabinoid spectrum
- Route of administration
- Lifestyle choices
- Medications the patient is already taking
Dr. Karen Keough, Chief Medical Officer at Compassionate Cultivation, created general dosage guidelines for dosing CBD oil to both adults and children who have epilepsy.
Dosing Recommendations for Children
Depending on the severity of symptoms, children may go through low-dose initiation and high-dose initiation.
Low-Dose Initiation instructions:
- Start with 0.25 mg/lb/day
- The minimum dose is 10 mg
- Target dose ranges between 1–5 mg/lb/day. Higher doses are tolerated but at the cost of some mild side effects, such as dry mouth, dry eyes, low blood pressure, sedation, and dizziness.
- Average dose is 1–3 mg/lb/day
- Increase the dose every 1–2 weeks by 0.5 mg/lb/day, topping to the nearest 10 mg as long as there are no side effects.
High-Dose Initiation in Children:
- Start with 0.5mg/lbs/day
- Target dose ranges between 1–5 mg/lb/day
- Average dose is 1-3 mg/lb/day
- Increase the dose every 1–2 weeks by 0.5 mg/lb/day and monitor the effects
- If side-effects occur, leave more time between dose increases and go up more gradually
Dosing Recommendations for Adults
Considering the factors above, such as body weight and metabolism, adults with epilepsy need more CBD in their regime than children. Use the following guidelines to reach an effective dose:
Low CBD dose in adults:
- Start with 25 mg twice daily
- Go up by 25 mg per dose every 1–2 weeks
- Target dose ranges between 100–300 mg twice a day if no side effects are observed. Clinical trials have utilized doses as high as 1,500 mg of CBD daily, but such high doses might not be necessary to achieve seizure relief in most patients
High CBD dose in adults:
- Start with 50 mg twice daily
- Go up every 1–2 weeks by 50 mg/dose
- Target dose ranges between 200–500 mg twice a day if tolerated. You may stop sooner if seizures are gone to prevent further dosage increase and possible side effects.
Where to Find CBD Oil for Sale for Epilepsy & Seizures
CBD oil is available both in cannabis dispensaries and online retail stores. Dispensaries give you access to a wide range of cannabis products, including CBD oil from hemp. However, these places may not always carry the best products, and the bottles have probably spent some time on the shelves before being sold so that they may lose potency over time due to poor storage.
That’s why I buy my CBD oil online. The majority of CBD stuff is sold this way, so you have more options to choose from. Also, you can verify the reputation of your potential vendor with the help of online research. Read user reviews, check for third-party lab reports, and learn how your company sources its CBD to make sure you’re getting a clean and potent product.
The delivery time for CBD oil is usually 2–3 business days. But in my opinion, it’s worth it to wait a few days more to get a high-quality product for a good price — CBD oil ordered online is usually less expensive than what you see in a dispensary.
Using CBD Oil for Seizures: Will It Help?
Cannabinoids have many proven beneficial effects on health, particularly in the treatment and management of epileptic seizures. Epilepsy is currently the only FDA-approved condition for treatment with CBD — although this approval doesn’t apply to hemp-derived CBD oil.
Still, if you want to try CBD oil for better management of your symptoms, I hope this guide has helped you understand how to use it to get the most out of its benefits. Just remember to start low and slow with the dosage.
But above all, consult with your doctor before purchasing any CBD product — just to make sure it won’t negatively interfere with any medications you’re taking.
Do you know any examples of people who successfully reduced the frequency of their seizures with CBD oil? Share your stories in the comments below!
CBD Oil for Seizures & Epilepsy: How Cannabis Oil Can Stop Seizures According to the Michigan Epilepsy Foundation, 1% of Americans suffer from some form of epilepsy — a recurring neurological