What is CBD bioavailability and how does it effect Absorption?
Cannabis is flying high on the wellness radar, because of Cannabidiol (CBD).
There are now a countless number of choices when deciding what type of CBD products to purchase and use.
Your choice of how you take CBD will impact how much of the compound reaches its final destination.
What does that mean?
Well, CBD and any other cannabinoid has to enter the endocannabinoid system and meet receptors in our body to be processed. But, this isn’t as simple as it might sound as it first needs to enter your bloodstream.
The amount of CBD which actually enters your bloodstream from consumption is a concept more commonly known as CBD bioavailability.
In this article, we will cover the most common ways to take CBD and discuss what current science suggests in regards to their advantages and disadvantages for absorption.
Before we dive in, let’s define how this happens within our body and what factors influence it.
Pharmacokinetics and CBD Bioavailability
Which method you use to administer your CBD will alter how much CBD gets absorbed and used by the body.
This process is more formally known as pharmacokinetics, which defines how compounds are processed within our body.
In this specific case, we are referring to how CBD is absorbed, metabolised, distributed and excreted .
The choice of administration method determines how quickly and how much of the cannabinoid enters our bloodstream, which is referred to as the bioavailability of CBD.
Which brings us nicely into our next point, covering the differences in CBD bioavailability between conventional consumption methods.
Bioavailability of CBD: Capsules, Pills, Edibles
Most of us are familiar with oral consumption when it comes to taking other supplements.
Oral CBD products are relatively popular, especially with people who are unable to use CBD tinctures for one reason or another. Edibles are also a booming segment, with CBD gummies becoming more commonplace day by day.
While popular, oral consumption, unfortunately, has the lowest rate CBD bioavailability.
With current research suggesting an absorption rate of somewhere between 13-19% and half-life of between roughly 1-2 hours .
When you consume oral CBD, most of it is wasted in the process of digestion via a process called the first-pass effect, leading to low bioavailability.
The fact CBD is fat-soluble makes it harder for our body to absorb. Additionally, our digestive enzymes destroy most of the compound before being metabolised by the liver. Thus, little CBD can enter the bloodstream.
On the more positive side, it might be possible that using oral CBD may lead to a more balanced set of effects across time when compared to say vaping CBD.
While the data is limited, animal-based research suggests that oral CBD consumption could lead to a longer duration of effects when compared to other methods of use.
CBD Inhalation: Vaping and Smoking
Inhaling CBD is a useful way to take CBD as it bypasses the first-pass effect by avoiding your digestive tract.
Instead, the CBD is inhaled directly into the lungs, where it is absorbed via membranes which cover the lungs called alveoli, after which the CBD can directly enter the bloodstream.
This is why when CBD is inhaled, the effects are felt rapidly but are also short-lasting compared to other methods
There are two main methods to inhale CBD, vaping and smoking:
Vaping: If you vape CBD the flower or concentrate is heated to a specific temperature where the cannabinoids in the bud or extract turn into an inhalable vapour. While there is no smoke and no combustion, there are still some risks associated with vaping, although these are significantly less than those related to smoking.
While it’s relatively clear vapourising CBD makes the compound more bioavailable for absorption in the bloodstream, the exact figures around how much are less precise.
This is because historical research has primarily focused on the bioavailability of THC when vapourised. Consequently, most research references assume the same absorption rate for CBD.
Nonetheless, based on this, research suggests the bioavailability of CBD, when vapourised, could be as high as 56% .
Smoking : Historically, this was the typical way to use cannabis. There is a piece of research which analysed the absorption rate of smoked CBD in the form of hemp flower-based cigarettes—concluding that smoking CBD had a bioavailability rate of 31% , with the half-life of smoked CBD being 31 hours.
CBD Bioavailability infers how much of a CBD dose reaches your bloodstream. Looking for a better way to consume CBD? Find out average absoprtion rates here.
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